Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

Pharmacol Rep. 2014 Oct;66(5):927-30. doi: 10.1016/j.pharep.2014.02.018. Epub 2014 Mar 13.

Abstract

Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.

Keywords: Epileptic afterdischarge; Hippocampus; Metabotropic glutamate receptor 5; Ontogeny; Rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / pharmacology*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Epilepsy, Complex Partial / drug therapy*
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Pyridines / administration & dosage
  • Pyridines / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptor, Metabotropic Glutamate 5 / antagonists & inhibitors*
  • Thiazoles / administration & dosage
  • Thiazoles / pharmacology*

Substances

  • 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine
  • Anticonvulsants
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Thiazoles