Biocompatible reactive oxygen species (ROS)-responsive nanoparticles as superior drug delivery vehicles

Adv Healthc Mater. 2015 Jan 7;4(1):69-76. doi: 10.1002/adhm.201400299. Epub 2014 Aug 22.

Abstract

A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well-defined ROS-sensitivity and superior biocompatibility. This nanocarrier can be used for ROS-triggered transport of diverse therapeutics and imaging agents.

Keywords: ROS-responsiveness; cyclodextrin; drug delivery; nanomedicine; tumor targeting.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials* / chemical synthesis
  • Biocompatible Materials* / chemistry
  • Biocompatible Materials* / pharmacology
  • Cell Line
  • Drug Carriers* / chemical synthesis
  • Drug Carriers* / chemistry
  • Drug Carriers* / pharmacology
  • Humans
  • Materials Testing*
  • Mice
  • Nanoparticles / chemistry*
  • Reactive Oxygen Species / chemistry
  • Reactive Oxygen Species / metabolism*

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Reactive Oxygen Species