Abstract
Cytomegalovirus resistance to antivirals is a major problem in transplant recipients. We evaluated the impact of five mutations (A594V, L595F, and E655K in the UL97 gene and V526L and E756K in the UL54 gene), detected in a blood sample from a stem cell transplant recipient, on drug susceptibilities and replicative capacities of recombinant viruses.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / pharmacology*
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Child, Preschool
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Cytomegalovirus / drug effects*
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Cytomegalovirus / genetics*
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Cytomegalovirus / isolation & purification
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Cytomegalovirus / physiology
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Cytomegalovirus Infections / virology*
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Drug Resistance, Viral*
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Female
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Hematopoietic Stem Cell Transplantation*
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Humans
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Immunocompromised Host
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Mutation, Missense*
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Virus Replication