Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping

J Clin Microbiol. 2014 Nov;52(11):4043-6. doi: 10.1128/JCM.02205-14. Epub 2014 Aug 20.

Abstract

Cytomegalovirus resistance to antivirals is a major problem in transplant recipients. We evaluated the impact of five mutations (A594V, L595F, and E655K in the UL97 gene and V526L and E756K in the UL54 gene), detected in a blood sample from a stem cell transplant recipient, on drug susceptibilities and replicative capacities of recombinant viruses.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Child, Preschool
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / genetics*
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus / physiology
  • Cytomegalovirus Infections / virology*
  • Drug Resistance, Viral*
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunocompromised Host
  • Mutation, Missense*
  • Virus Replication

Substances

  • Antiviral Agents