Abstract
We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Line, Tumor
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Chelating Agents / chemistry
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Contrast Media / chemical synthesis
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Contrast Media / chemistry*
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Contrast Media / metabolism
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / metabolism
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Fluorescent Dyes / chemistry
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Gadolinium / chemistry
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HeLa Cells
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Humans
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Magnetic Resonance Imaging*
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Mice
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Microscopy, Confocal
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Optical Imaging
Substances
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Chelating Agents
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Contrast Media
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Coordination Complexes
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Fluorescent Dyes
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Gadolinium