Fucosylated chondroitin sulfate diversity in sea cucumbers: a review

Pang Myron; Shafiquzzaman Siddiquee; Sujjat Al Azad

doi:10.1016/j.carbpol.2014.05.091

Fucosylated chondroitin sulfate diversity in sea cucumbers: a review

Carbohydr Polym. 2014 Nov 4:112:173-8. doi: 10.1016/j.carbpol.2014.05.091. Epub 2014 Jun 6.

Authors

Pang Myron¹, Shafiquzzaman Siddiquee², Sujjat Al Azad¹

Affiliations

¹ Borneo Marine Research Institute, University Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.
² Biotechnology Research Institute, University Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. Electronic address: shafiqpab@ums.edu.my.

PMID: 25129732
DOI: 10.1016/j.carbpol.2014.05.091

Abstract

Fucosylated chondroitin sulfate (FucCS) is structurally distinct glycosaminoglycans found from the sea cucumber body wall consisted of chondroitin sulfate type backbone with attached sulfated or non-sulfated fucose side chain. Structurally this compound plays an important role in maintaining the body wall integrity and possesses a wide spectrum of biological activities. Recently several glycosaminoglycans' structures have been solved to elucidate its physicochemical activity. The purpose of this review paper is to elaborate existing structural properties and functions, reporting over 30 years and systematically discussion herein.

Keywords: Chondroitin sulfate; Fucose; Holothurians; Structure; Sulfated glycosaminoglycans.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carbohydrate Sequence
Chondroitin Sulfates / chemistry*
Chondroitin Sulfates / metabolism
Molecular Sequence Data
Sea Cucumbers / chemistry*

Substances

fucosylated chondroitin sulfate
Chondroitin Sulfates