Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes

Cell Host Microbe. 2014 Aug 13;16(2):153-155. doi: 10.1016/j.chom.2014.07.010.

Abstract

Two reports in this issue of Cell Host & Microbe (Sellin et al., 2014; Knodler et al., 2014) establish the cell-intrinsic inflammasome-induced extrusion of infected enterocytes as a general defense mechanism against acute bacterial infections.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / physiology*
  • Calcium-Binding Proteins / physiology*
  • Caspases / metabolism*
  • Caspases, Initiator / metabolism*
  • Enterocytes / microbiology*
  • Escherichia coli Infections / enzymology*
  • Humans
  • Inflammasomes / physiology*
  • Neuronal Apoptosis-Inhibitory Protein / physiology*
  • Salmonella Infections / enzymology*
  • Salmonella Infections / immunology*
  • Salmonella typhimurium / immunology*

Substances

  • Apoptosis Regulatory Proteins
  • Calcium-Binding Proteins
  • Inflammasomes
  • Ipaf protein, mouse
  • Naip1 protein, mouse
  • Neuronal Apoptosis-Inhibitory Protein
  • CASP4 protein, human
  • Casp4 protein, mouse
  • Caspases
  • Caspases, Initiator