Women with osteoarthritis have elevated synovial fluid levels of insulin-like growth factor (IGF)-1 and IGF-binding protein-3

J Immunoassay Immunochem. 2015;36(3):284-94. doi: 10.1080/15321819.2014.947431.

Abstract

The present study explores the possible connection between synovial fluid concentrations of insulin like growth factor (IGF-1), IGF-binding protein (IGFBP-3), leptin, and C-reactive protein (CRP) in osteoarthritis (OA). Synovial fluid specimens were obtained from a total of thirty-four individuals with and without OA. Protein-normalized measurements of IGF-1, IGFBP-3, and leptin concentrations in synovial fluid showed significantly (P < 0.05) elevated levels in women with knee OA but not in men. This study provides initial evidence that protein normalized IGF-1 and IGFBP-3 and leptin levels increase in synovial fluid of women but not in men with OA versus those without OA.

Keywords: C-reactive protein; cartilage; insulin-like growth factor; leptin; osteoarthritis; synovial fluid.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • C-Reactive Protein / metabolism
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / metabolism*
  • Insulin-Like Growth Factor I / metabolism*
  • Leptin / metabolism
  • Male
  • Middle Aged
  • Osteoarthritis / metabolism*
  • Osteoarthritis / pathology
  • Sex Characteristics*
  • Synovial Fluid / metabolism*

Substances

  • IGFBP3 protein, human
  • Insulin-Like Growth Factor Binding Protein 3
  • Leptin
  • Insulin-Like Growth Factor I
  • C-Reactive Protein