Mechanistic studies of Gd3+-based MRI contrast agents for Zn2+ detection: towards rational design

Chemistry. 2014 Aug 25;20(35):10959-69. doi: 10.1002/chem.201403043. Epub 2014 Aug 12.

Abstract

A series of novel pyridine-based Gd(3+) complexes have been prepared and studied as potential MRI contrast agents for Zn(2+) detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn(2+) binding in terms of variations of the rotational motion.

Keywords: NMR spectroscopy; lanthanides; relaxation; sensors; zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemical synthesis*
  • Contrast Media / chemistry
  • Drug Stability
  • Fluorescent Dyes / chemistry
  • Gadolinium / chemistry*
  • Ligands
  • Magnetic Resonance Imaging*
  • Models, Molecular
  • Zinc / analysis*
  • Zinc / chemistry

Substances

  • Contrast Media
  • Fluorescent Dyes
  • Ligands
  • Gadolinium
  • Zinc