Abstract
We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.
MeSH terms
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Acetic Acid
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Aconitine / analogs & derivatives
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Aconitine / isolation & purification
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Aconitine / pharmacology
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Aconitum / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Analgesics / isolation & purification
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Analgesics / pharmacology*
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Animals
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Animals, Outbred Strains
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Arthritis, Experimental / chemically induced
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Arthritis, Experimental / physiopathology
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Dipyrone / pharmacology
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Freund's Adjuvant
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Injections, Intraperitoneal
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Mice
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Pain / chemically induced
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Pain / physiopathology
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Pain / prevention & control*
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Plant Extracts / chemistry
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Rats
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Seizures / chemically induced
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Seizures / physiopathology
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Seizures / prevention & control*
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Vocalization, Animal / drug effects
Substances
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Alkaloids
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Analgesics
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Plant Extracts
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napelline
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hypaconitine
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mesaconitine
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Dipyrone
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songorine
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Freund's Adjuvant
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Acetic Acid
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Aconitine