Total synthesis of Polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy

Gajan Santhakumar; Richard J Payne

doi:10.1021/ol502045u

Total synthesis of Polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy

Org Lett. 2014 Sep 5;16(17):4500-3. doi: 10.1021/ol502045u. Epub 2014 Aug 8.

Authors

Gajan Santhakumar¹, Richard J Payne

Affiliation

¹ School of Chemistry, The University of Sydney , Sydney, NSW 2006, Australia.

PMID: 25105901
DOI: 10.1021/ol502045u

Abstract

The first total syntheses of the marine sponge-derived cyclic depsipeptide natural products Polydiscamides B, C, and D are described. The molecules were constructed through the convergent fusion of cyclic and linear fragments via an unprecedented native chemical ligation-oxidation protocol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Products / chemical synthesis*
Biological Products / chemistry
Marine Biology
Molecular Structure
Oxidation-Reduction
Peptides, Cyclic / chemical synthesis*
Peptides, Cyclic / chemistry
Porifera / chemistry

Substances

Biological Products
Peptides, Cyclic
polydiscamide B
polydiscamide C
polydiscamide D