Abstract
A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations.
MeSH terms
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Acrylates / chemical synthesis*
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Acrylates / chemistry
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Acrylates / pharmacology*
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / chemistry
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Benzimidazoles / pharmacology*
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Catalysis
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Hepacivirus / drug effects
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Hepacivirus / enzymology
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Ligands
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Molecular Structure
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Palladium / chemistry
Substances
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Acrylates
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Antiviral Agents
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Benzimidazoles
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Ligands
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deleobuvir
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Palladium