Relationship between paraoxonase 1 activity and high density lipoprotein concentration during naturally occurring babesiosis in dogs

Res Vet Sci. 2014 Oct;97(2):318-24. doi: 10.1016/j.rvsc.2014.07.010. Epub 2014 Jul 22.

Abstract

Paraoxonase 1 (PON1) is a negative acute phase protein bound to high density lipoproteins (HDL) and during the acute phase response (APR) protects HDL from peroxidation. The aim of this study was to assess the relationship between PON1 and HDL in canine babesiosis, a disease characterized by oxidative damages and by an APR. PON1, HDL and C-reactive protein (CRP), were measured in blood collected from 15 controls and 29 dogs with babesiosis sampled at admission, and on days 1 and 7 after treatment. At admission, PON1 and HDL were significantly lower in affected dogs. HDL concentration increased at day 1 while PON1 increased and CRP decreased at day 7. This suggests that the decrease of PON1 at admission is in part due to an increased consumption, the decreased HDL may depend on lipid peroxidation and its rapid increase after treatment may depend on the antioxidant activity of PON1.

Keywords: Babesiosis; C-reactive protein (CRP); HDL-Cholesterol; Oxidation; Paraoxonase-1 (PON1).

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antiprotozoal Agents / therapeutic use
  • Aryldialkylphosphatase / blood*
  • Babesiosis / blood*
  • Babesiosis / drug therapy
  • Babesiosis / physiopathology*
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Dog Diseases / blood*
  • Dog Diseases / drug therapy
  • Dog Diseases / physiopathology*
  • Dogs
  • Imidocarb / analogs & derivatives
  • Imidocarb / therapeutic use
  • Lipid Peroxidation / physiology
  • Lipoproteins, HDL / blood*
  • Oxidation-Reduction
  • Prospective Studies
  • Treatment Outcome

Substances

  • Antiprotozoal Agents
  • Biomarkers
  • Lipoproteins, HDL
  • Imidocarb
  • C-Reactive Protein
  • Aryldialkylphosphatase
  • imidocarb dipropionate