Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells

Erik Berk; Shuwen Xu; Brian J Czerniecki

doi:10.4161/onci.27617

Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells

Oncoimmunology. 2014 Jan 6:3:e27617. doi: 10.4161/onci.27617. eCollection 2014.

Authors

Erik Berk¹, Shuwen Xu¹, Brian J Czerniecki²

Affiliations

¹ Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA.
² Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA ; Rena Rowan Breast Center; University of Pennsylvania; Philadelphia, PA USA.

Abstract

Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting T_H1-like cells that express the transcription factor T-bet.

Keywords: FOXP3; T-bet; dendritic cells; interferon γ; regulatory T cells.