Insights into EPR effect versus lectin-mediated targeted delivery: biodegradable polycarbonate micellar nanoparticles with and without galactose surface decoration

Amalina Binte Ebrahim Attia; Pamela Oh; Chuan Yang; Jeremy Pang Kern Tan; Nithya Rao; James L Hedrick; Yi Yan Yang; Ruowen Ge

doi:10.1002/smll.201401295

Insights into EPR effect versus lectin-mediated targeted delivery: biodegradable polycarbonate micellar nanoparticles with and without galactose surface decoration

Small. 2014 Nov 12;10(21):4281-6. doi: 10.1002/smll.201401295. Epub 2014 Aug 4.

Authors

Amalina Binte Ebrahim Attia¹, Pamela Oh, Chuan Yang, Jeremy Pang Kern Tan, Nithya Rao, James L Hedrick, Yi Yan Yang, Ruowen Ge

Affiliation

¹ Institute of Bioengineering and Nanotechnology (IBN), 31 Biopolis Way, The Nanos, #04-10, 138669, Singapore.

PMID: 25091699
DOI: 10.1002/smll.201401295

Abstract

Polymeric micelles with and without galactose are synthesized to study liver targeting ability in an orthotopic HCC rat model. Micelles with galactose accumulate more in the healthy liver tissue instead of HCC, while micelles without galactose amass in HCC by the EPR effect. These micelles show great potential as drug delivery carriers to target either the liver or HCC.

Keywords: biodistribution; galactose; liver targeting; micelles; polycarbonates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biodegradable Plastics* / chemical synthesis
Biodegradable Plastics* / chemistry
Biodegradable Plastics* / pharmacokinetics
Carcinoma, Hepatocellular / metabolism
Carcinoma, Hepatocellular / pathology
Cell Membrane Permeability / drug effects*
Coated Materials, Biocompatible / chemical synthesis
Coated Materials, Biocompatible / chemistry
Coated Materials, Biocompatible / pharmacokinetics*
Drug Carriers / chemical synthesis
Drug Carriers / chemistry
Drug Carriers / pharmacokinetics*
Drug Delivery Systems* / instrumentation
Drug Delivery Systems* / methods
Galactose / chemistry*
Galectin 3 / administration & dosage
Galectin 3 / chemistry
Galectin 3 / pharmacokinetics
Humans
Lectins / chemistry*
Liver Neoplasms / metabolism
Liver Neoplasms / pathology
Micelles
Nanoparticles / chemistry*
Nanoparticles / therapeutic use
Polycarboxylate Cement / chemistry*
Rats
Rats, Inbred BUF
Surface Properties
Tumor Cells, Cultured
Xenograft Model Antitumor Assays / instrumentation
Xenograft Model Antitumor Assays / methods

Substances

Biodegradable Plastics
Coated Materials, Biocompatible
Drug Carriers
Galectin 3
Lectins
Micelles
Polycarboxylate Cement
polycarbonate
Galactose