Japodagricanones A and B, novel diterpenoids from Jatropha podagrica

Fitoterapia. 2014 Oct:98:156-9. doi: 10.1016/j.fitote.2014.07.021. Epub 2014 Aug 1.

Abstract

Two novel diterpenoids, japodagricanones A (1) and B (2), along with their biogenetically related diterpenoid 15-epi-4E-jatrogrossidentadion (3), were isolated from the leaves and twigs of Jatropha podagrica. Japodagricanones A (1) and B (2) are the first C-5-nor lathyrane-type diterpenoids. Their structures were established using spectroscopic data, including MS, NMR and ECD data. A plausible biosynthetic pathway for their generation was also proposed.

Keywords: Diterpenoids; Japodagricanone A; Japodagricanone B; Jatropha podagrica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Humans
  • Jatropha / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • japodagricanone A
  • japodagricanone B