Abstract
Rhytidenone A (1), a unique spirobisnaphthalene with a 1,7-dioxaspiro[4,4]nonan-2-one motif, and five new spirobisnaphthalenes, rhytidenones B-F (2-6), were isolated from the extract of a cultured fungal endophyte, Rhytidhysteron sp. AS21B. Their structures were elucidated mainly by analysis of NMR spectroscopic data. The structure and configuration of 1 were further confirmed by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC50 values of 0.31 and 3.60 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ascomycota / chemistry*
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Crystallography, X-Ray
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Female
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Indomethacin / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Conformation
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / microbiology
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Salvadoraceae / microbiology
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Thailand
Substances
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Naphthalenes
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Spiro Compounds
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rhytidenone A
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Indomethacin