Sliding filaments and mitotic spindle organization

Nat Cell Biol. 2014 Aug;16(8):737-9. doi: 10.1038/ncb3019.

Abstract

Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs - nucleated at centrosomes, chromosomes and on pre-existing MTs - contributes to spindle assembly and length control.

Publication types

  • Comment

MeSH terms

  • Humans
  • Microtubules / metabolism*
  • Spindle Apparatus / metabolism*