Chemical constituents of Abies nukiangensis

Yong-Li Li; Yan-Xia Gao; Hui-Zi Jin; Lei Shan; Xue-Song Liang; Xi-Ke Xu; Xian-Wen Yang; Ning Wang; Andre Steinmetz; Zhilei Chen; Wei-Dong Zhang

doi:10.1016/j.phytochem.2014.07.003

Chemical constituents of Abies nukiangensis

Phytochemistry. 2014 Oct:106:116-123. doi: 10.1016/j.phytochem.2014.07.003. Epub 2014 Jul 28.

Authors

Yong-Li Li¹, Yan-Xia Gao², Hui-Zi Jin², Lei Shan³, Xue-Song Liang⁴, Xi-Ke Xu³, Xian-Wen Yang⁵, Ning Wang⁶, Andre Steinmetz⁶, Zhilei Chen⁷, Wei-Dong Zhang⁸

Affiliations

¹ School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China.
² School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
³ School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
⁴ Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; Artie McFerrin Department of Chemical Engineering, Texas A&M University, TX 77843, USA.
⁵ Luxembourg Public Research Centre for Health (CRP-Sante), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. Electronic address: xianwen.yang@crp-sante.lu.
⁶ Luxembourg Public Research Centre for Health (CRP-Sante), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
⁷ Artie McFerrin Department of Chemical Engineering, Texas A&M University, TX 77843, USA.
⁸ School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: wdzhangy@hotmail.com.

PMID: 25081106
DOI: 10.1016/j.phytochem.2014.07.003

Abstract

During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25μM, respectively.

Keywords: Abies nukiangensis; Abietoideae; Cu-Kα X-ray crystallography; Hepatitis C virus (HCV); Pinaceae; Triterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abies / chemistry*
Antiviral Agents / chemistry*
Antiviral Agents / isolation & purification
Cell Line, Tumor
Hepacivirus / drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Phenols / chemistry*
Phenols / isolation & purification
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
Triterpenes / chemistry*
Triterpenes / isolation & purification

Substances

Antiviral Agents
Phenols
Plant Extracts
Triterpenes