The management of valvular heart diseases with mechanical valves has been performed for several years. Warfarin has been used in patients with mechanical heart valves to protect against thromboembolic complications; nevertheless, in these patients, thromboembolic event rates range from 0.5% to 1.7%. Acute occlusive embolism to the coronary arteries due to a mechanical valve is an uncommon occurrence. In this report, we present a case of a left coronary system occlusion due to thrombus embolization from a prosthetic aortic valve, which was successfully treated by thrombolytic therapy.