Poly(oligonucleotide)

J Am Chem Soc. 2014 Aug 13;136(32):11216-9. doi: 10.1021/ja503142s. Epub 2014 Jul 31.

Abstract

Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemistry
  • DNA, Single-Stranded / chemistry
  • Magnetic Resonance Spectroscopy
  • Nanoparticles / chemistry
  • Oligonucleotides / chemistry*
  • Peptide Nucleic Acids / chemistry*
  • Polymerization
  • Polymers / chemistry

Substances

  • DNA, Single-Stranded
  • Oligonucleotides
  • Peptide Nucleic Acids
  • Polymers
  • DNA

Grants and funding

National Institutes of Health, United States