Abstract
The case is described of a frail patient who developed prosthetic valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA). Conventional antimicrobial treatments either failed or were contraindicated, and the patient was judged unsuitable for a further valve replacement. A salvage therapy with high doses of a new cephalosporin, ceftaroline, given three times daily was undertaken; subsequently, the patient had not relapsed at two months after completing a six-week course of ceftaroline. Ceftaroline deserves major attention as an alternative choice in difficult-to-treat MRSA endocarditis.
MeSH terms
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Aged
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Anti-Bacterial Agents / administration & dosage*
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Ceftaroline
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Cephalosporins / administration & dosage*
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Endocarditis, Bacterial / diagnosis
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Frail Elderly
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Heart Valve Prosthesis / adverse effects*
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Heart Valve Prosthesis Implantation / adverse effects*
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Heart Valve Prosthesis Implantation / instrumentation*
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Humans
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Male
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Methicillin-Resistant Staphylococcus aureus / isolation & purification*
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Prosthesis-Related Infections / diagnosis
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Staphylococcal Infections / diagnosis
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Cephalosporins