Spontaneous mutation results in loss of the cytadhesin (P1) of Mycoplasma pneumoniae

Infect Immun. 1989 Oct;57(10):3237-9. doi: 10.1128/iai.57.10.3237-3239.1989.

Abstract

The cytadhesin (P1) structural gene of a spontaneous mutant of Mycoplasma pneumoniae which displayed a P1-negative phenotype was analyzed. An extra adenine was discovered in a stretch of normally seven adenines near the N-terminal region of the mutant P1 structural gene. The frameshift mutation resulted in the early termination of protein translation. Possible causes of the mutation are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adhesins, Bacterial*
  • Amino Acid Sequence
  • Bacterial Adhesion*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / isolation & purification
  • Base Sequence
  • Genes
  • Genes, Bacterial*
  • Molecular Sequence Data
  • Mutation*
  • Mycoplasma pneumoniae / genetics*

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • adhesin, Mycoplasma pneumoniae