Antithrombotic reversal agents

Matthew D Wilson; Jonathan E Davis

doi:10.1016/j.emc.2014.04.013

Antithrombotic reversal agents

Emerg Med Clin North Am. 2014 Aug;32(3):715-25. doi: 10.1016/j.emc.2014.04.013. Epub 2014 Jun 7.

Authors

Matthew D Wilson¹, Jonathan E Davis²

Affiliations

¹ Department of Emergency Medicine, Georgetown University Hospital, Washington Hospital Center, 110 Irving Street, NA 1177, Washington, DC 20010, USA.
² Department of Emergency Medicine, Georgetown University Hospital, Washington Hospital Center, 110 Irving Street, NA 1177, Washington, DC 20010, USA. Electronic address: jdthere@gmail.com.

PMID: 25060258
DOI: 10.1016/j.emc.2014.04.013

Abstract

The actively bleeding anticoagulated patient presenting to the emergency department requires rapid evaluation and treatment, which is made increasingly complicated by the ever-evolving antithrombotic treatment options used in medicine. Even with excellent supportive care, the timeliness with which reversal decisions need to be made continues to demand of the emergency practitioner a familiarity with the properties and general characteristics of a variety of antithrombotic agents. Reversal options vary and may include vitamin K, FFP, PCC, rFVIIa, platelets, and desmopressin, among others.

Keywords: Anticoagulate; Antithrombotic reversal agent; Bleeding; Coagulopathic; Emergency department; Reversal options.

Publication types

Review

MeSH terms

Antifibrinolytic Agents / therapeutic use*
Blood Coagulation Factors / therapeutic use
Emergency Service, Hospital
Fibrinolytic Agents / adverse effects*
Hemorrhage / drug therapy*
Hemorrhage / etiology
Hemostasis / drug effects
Hemostasis / physiology*
Humans
Vitamin K / therapeutic use

Substances

Antifibrinolytic Agents
Blood Coagulation Factors
Fibrinolytic Agents
Vitamin K
prothrombin complex concentrates