[Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture]

Antibiot Khimioter. 2014;59(1-2):3-5.
[Article in Russian]

Abstract

The efficacy of Triazavirin against the tick-borne encephalitis virus was estimated in the sensitive cell culture vs. the active drug Ribavirin. In a concentration of 128 mcg/ml Triazavirin was shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture.

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / pharmacology*
  • Azoles / chemical synthesis
  • Azoles / pharmacology*
  • Cell Line
  • Encephalitis Viruses, Tick-Borne / drug effects*
  • Encephalitis Viruses, Tick-Borne / physiology
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects*
  • Epithelial Cells / virology
  • Kidney / cytology
  • Kidney / drug effects*
  • Kidney / virology
  • Ribavirin / pharmacology
  • Swine
  • Triazines / chemical synthesis
  • Triazines / pharmacology*
  • Triazoles
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Azoles
  • Triazines
  • Triazoles
  • Ribavirin
  • riamilovir