Background: Cross-species transmission of AA amyloidosis between primates and other animals has not been previously reported.
Methods: Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation.
Results: AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically.
Conclusions: These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.
Keywords: AA amyloidosis; amyloid A; amyloid β; cattle; chicken; chimpanzee; transmission.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.