Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis

Yan-Hui Fu; Shun-Lin Li; Shi-Fei Li; Hong-Ping He; Ying-Tong Di; Yu Zhang; Xiao-Jiang Hao

doi:10.1016/j.fitote.2014.07.008

Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis

Fitoterapia. 2014 Oct:98:45-52. doi: 10.1016/j.fitote.2014.07.008. Epub 2014 Jul 16.

Authors

Yan-Hui Fu¹, Shun-Lin Li², Shi-Fei Li², Hong-Ping He², Ying-Tong Di², Yu Zhang³, Xiao-Jiang Hao⁴

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: zhangyu@mail.kib.ac.cn.
⁴ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: haoxj@mail.kib.ac.cn.

PMID: 25038470
DOI: 10.1016/j.fitote.2014.07.008

Abstract

Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.

Keywords: Bisindole alkaloids; Bousigonia mekongensis; Cytotoxicity; Mekongenines C–F.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Apocynaceae / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / isolation & purification
Indole Alkaloids / pharmacology*
Inhibitory Concentration 50
Molecular Structure
Plant Leaves / chemistry
Quinolines / isolation & purification
Quinolines / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
Quinolines
aspidospermine