Inappropriate antidiuretic hormone secretion due to squamous cell lung cancer

Asian Cardiovasc Thorac Ann. 2015 Jun;23(5):579-81. doi: 10.1177/0218492314544128. Epub 2014 Jul 17.

Abstract

The syndrome of inappropriate secretion of antidiuretic hormone is a disorder of impaired water excretion caused by the inability to suppress secretion of antidiuretic hormone. It has been commonly associated with small cell carcinoma. The association of this syndrome with squamous cell lung carcinoma has rarely been reported, with only 4 cases over the past two decades in the English literature. We describe the case of a 75-year-old Caucasian male who developed the syndrome after a right pneumonectomy for down-staged squamous cell lung cancer previously treated with neoadjuvant platinum-based chemotherapy and radiotherapy.

Keywords: Carcinoma; hyponatremia; inappropriate ADH syndrome; lung neoplasms; non-small-cell lung; pneumonectomy; vasopressins.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / blood
  • Carcinoma, Squamous Cell / complications*
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / radiotherapy
  • Carcinoma, Squamous Cell / surgery
  • Chemoradiotherapy / methods
  • Humans
  • Inappropriate ADH Syndrome / blood
  • Inappropriate ADH Syndrome / etiology*
  • Lung Neoplasms / complications*
  • Male
  • Paraneoplastic Syndromes / blood
  • Paraneoplastic Syndromes / etiology*
  • Pneumonectomy / methods
  • Vasopressins / blood

Substances

  • Vasopressins