Desmodianone H and uncinanone B, potential tyrosinase inhibitors obtained from Lespedeza maximowiczii by using bioactivity-guided isolation

Biosci Biotechnol Biochem. 2014;78(6):943-5. doi: 10.1080/09168451.2014.905180. Epub 2014 May 28.

Abstract

A new bioactive compound, namely desmodianone H(1), and another known compound uncinanone B(2) were first isolated using bioactivity-guided isolation from the leaves of Lespedeza maximowiczii and structures were elucidated by comprehensive analysis of their nuclear magnetic resonance and mass spectrometry data. Compounds 1 and 2 exhibited strong inhibitory effects on mushroom tyrosinase activity.

Keywords: Lespedeza maximowiczii; desmodianone H; tyrosinase inhibition activity; uncinanone B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / enzymology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology*
  • Isoflavones / chemistry
  • Isoflavones / isolation & purification*
  • Isoflavones / pharmacology*
  • Lespedeza / chemistry*
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Plant Leaves / chemistry

Substances

  • Enzyme Inhibitors
  • Isoflavones
  • desmodianone H
  • uncinanone B
  • Monophenol Monooxygenase