Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-CHOP therapy and intrathecal administration: a case report and review of literature

Yasunobu Sekiguchi; Asami Shimada; Hidenori Imai; Mutsumi Wakabayashi; Keiji Sugimoto; Noriko Nakamura; Tomohiro Sawada; Norio Komatsu; Masaaki Noguchi

Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-CHOP therapy and intrathecal administration: a case report and review of literature

Int J Clin Exp Pathol. 2014 May 15;7(6):3363-9. eCollection 2014.

Authors

Yasunobu Sekiguchi¹, Asami Shimada¹, Hidenori Imai², Mutsumi Wakabayashi¹, Keiji Sugimoto¹, Noriko Nakamura³, Tomohiro Sawada³, Norio Komatsu⁴, Masaaki Noguchi¹

Affiliations

¹ Department of Hematology, Juntendo University Urayasu Hospital Japan.
² Shibanishi Clinic Japan.
³ Department of Clinical Laboratory, Juntendo University Urayasu Hospital Japan.
⁴ Department of Hematology, Juntendo University Hospital Japan.

PMID: 25031761
PMCID: PMC4097275

Abstract

A 46-year-old man developed a fever and cough, and computed tomography showed multiple, nodular infiltrative shadows in lungs. He was diagnosed as having intravascular large B-cell lymphoma (IVLBCL). Brain magnetic resonance imaging (MRI, T2W1) showed an abnormal signal area in the pons, which was IVLBCL involvement. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy and intrathecal (I.T.) injection of methotrexate, cytarabine and prednisolone were selected. Complete remission (CR) was achieved and pontine involvement disappeared. A total of 8 courses of R-CHOP therapy and 4 courses of I.T. were performed. CR has been maintained for 1 year and 2 months.

Keywords: CHOP therapy; Intravascular large B-cell lymphoma; central nervous system involvement; intrathecal administration; rituximab.

Publication types

Case Reports
Review

MeSH terms

Antibodies, Monoclonal, Murine-Derived / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain Neoplasms / drug therapy*
Brain Neoplasms / pathology
Cyclophosphamide / therapeutic use
Cytarabine / administration & dosage
Doxorubicin / therapeutic use
Humans
Injections, Spinal
Lung Neoplasms / drug therapy
Lung Neoplasms / pathology
Lymphoma, B-Cell / drug therapy*
Lymphoma, B-Cell / pathology*
Male
Methotrexate / administration & dosage
Middle Aged
Pons / pathology*
Prednisolone / administration & dosage
Prednisone / therapeutic use
Remission Induction
Rituximab
Vascular Neoplasms
Vincristine / therapeutic use

Substances

Antibodies, Monoclonal, Murine-Derived
R-CHOP protocol
Cytarabine
Rituximab
Vincristine
Doxorubicin
Cyclophosphamide
Prednisolone
Prednisone
Methotrexate