Which patients have greatest need for elvitegravir/cobicistat/ emtricitabine/tenofovirDF-based therapy?

Recent Pat Antiinfect Drug Discov. 2014;9(1):41-51. doi: 10.2174/1574891x09666140717102358.

Abstract

Elvitegravir/cobicistat/emtricitabine/tenofovirDF (EVG/COBI/FTC/TDF) is the new single-tablet, fixed-dose formulation containing an integrase strand transfer inhibitor recently approved as antiretroviral treatment. In this paper we analysed its use and advantages in naïve and experienced HIV-infected patients and we focused on special populations in which EVG/COBI/FTC/TDF could be a suitable option. Furthermore the manuscript reports the recent patent of EVG which may have an influence on the management of HIV-infected patients in the next future.

Publication types

  • Review

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / therapeutic use
  • Anti-HIV Agents / therapeutic use*
  • Carbamates / therapeutic use*
  • Cobicistat
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / therapeutic use
  • Drug Combinations
  • Emtricitabine
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects
  • Humans
  • Patents as Topic
  • Phosphorous Acids / therapeutic use*
  • Quinolones / therapeutic use*
  • Thiazoles / therapeutic use*

Substances

  • 9-(2-((bis(pivaloyloxymethoxy)phosphinoyl)methoxy)propyl)adenine
  • Anti-HIV Agents
  • Carbamates
  • Drug Combinations
  • Phosphorous Acids
  • Quinolones
  • Thiazoles
  • Deoxycytidine
  • elvitegravir
  • Emtricitabine
  • Adenine
  • Cobicistat