MRI nanoprobes based on chemical exchange saturation transfer: Ln(III) chelates anchored on the surface of mesoporous silica nanoparticles

Giuseppe Ferrauto; Fabio Carniato; Lorenzo Tei; He Hu; Silvio Aime; Mauro Botta

doi:10.1039/c4nr02753a

MRI nanoprobes based on chemical exchange saturation transfer: Ln(III) chelates anchored on the surface of mesoporous silica nanoparticles

Nanoscale. 2014 Aug 21;6(16):9604-7. doi: 10.1039/c4nr02753a.

Authors

Giuseppe Ferrauto¹, Fabio Carniato, Lorenzo Tei, He Hu, Silvio Aime, Mauro Botta

Affiliation

¹ Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza, 52, 10126, Torino, Italy. silvio.aime@unito.it.

PMID: 25029466
DOI: 10.1039/c4nr02753a

Abstract

The formation of ternary complexes between neutral Ln(III)-DO3A chelates anchored on MCM-41 mesoporous silica nanoparticles (MSNs) and silanol groups on the surface allows obtaining highly efficient chemical exchange saturation transfer (CEST) MRI nanoprobes. These new probes achieve excellent sensitivity in the μM range (per Ln(III) ion), significantly greater than that of other paramagnetic CEST nanosystems such as dendrimers or micelles and three orders of magnitude higher than that of the corresponding molecular agents.

Publication types

Research Support, Non-U.S. Gov't