Uncommon chlorinated xanthone and other antibacterial compounds from the lichen Cladonia incrassata

Planta Med. 2014 Jul;80(11):931-5. doi: 10.1055/s-0034-1382827. Epub 2014 Jul 16.

Abstract

Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (-)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (-)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Aspergillus / drug effects
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology*
  • Candida albicans / drug effects
  • Halogenation
  • Lichens / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Staphylococcus aureus / drug effects
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification
  • Xanthenes / pharmacology*
  • Xanthones / chemistry
  • Xanthones / isolation & purification
  • Xanthones / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Benzofurans
  • Xanthenes
  • Xanthones
  • cladoxanthone A
  • usnic acid
  • xanthone