Norcassane- and cassane-type furanoditerpenoids from the seeds of Caesalpinia sappan

Fitoterapia. 2014 Oct:98:22-6. doi: 10.1016/j.fitote.2014.07.001. Epub 2014 Jul 10.

Abstract

Three novel furanoditerpenoids, norcaesalpinin J (1) featuring an unusual 20-norcassane hydroperoxide and phangininoxys B (2) and C (3) possessing cassane hemiketal skeletons, were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated by extensive spectroscopic methods. All isolates were evaluated for the cytotoxic activities on three human cancer cell lines.

Keywords: Caesalpinia sappan; Cytotoxicity; Norcassane diterpene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caesalpinia / chemistry*
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Humans
  • Molecular Structure
  • Seeds / chemistry*

Substances

  • Diterpenes
  • norcaesalpinin J
  • phangininoxy B
  • phangininoxy C