Anti-aquaporin-4 antibody-positive dorsal midbrain syndrome

Mult Scler. 2015 Apr;21(4):477-80. doi: 10.1177/1352458514541977. Epub 2014 Jul 10.

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) can cause various ocular motor disorders in addition to optic neuritis. Ocular motor findings associated with NMOSD include spontaneous vertical and gaze-evoked nystagmus, wall-eyed bilateral internuclear ophthalmoplegia, and trochlear nerve palsy. The association between dorsal midbrain syndrome and anti-aquaporin-4 antibody seropositivity has not been reported. Here, we report a patient displaying typical dorsal midbrain syndrome and anti-aquaporin-4 antibody seropositivity.

Keywords: Dorsal midbrain syndrome; aquaporin-4; neuromyelitis optica.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aquaporin 4 / immunology
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Brain Diseases / immunology
  • Brain Diseases / physiopathology*
  • Female
  • Humans
  • Mesencephalon / pathology*
  • Middle Aged
  • Neuromyelitis Optica / immunology
  • Neuromyelitis Optica / physiopathology*
  • Syndrome

Substances

  • AQP4 protein, human
  • Aquaporin 4
  • Autoantibodies
  • Autoantigens