A modular designed copolymer with anti-thrombotic activity and imaging capability

Nan Xie; Ke Feng; Bin Chen; Ming Zhao; Li-Ping Zhang; Chen-Ho Tung; Li-Zhu Wu; Shiqi Peng

doi:10.1039/c4cc04649h

A modular designed copolymer with anti-thrombotic activity and imaging capability

Chem Commun (Camb). 2014 Aug 28;50(67):9539-42. doi: 10.1039/c4cc04649h.

Authors

Nan Xie¹, Ke Feng, Bin Chen, Ming Zhao, Li-Ping Zhang, Chen-Ho Tung, Li-Zhu Wu, Shiqi Peng

Affiliation

¹ School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China. mingzhao@bjmu.edu.cn sqpeng@bjmu.edu.cn.

PMID: 25012142
DOI: 10.1039/c4cc04649h

Abstract

Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Design*
Fibrinolytic Agents / chemistry*
Fibrinolytic Agents / pharmacology*
Molecular Imaging / methods*
Oligopeptides / chemistry
Polyethylene Glycols / chemistry
Polymerization
Polymers / chemistry*
Polymers / pharmacology*
Rhodamines / chemistry

Substances

Fibrinolytic Agents
Oligopeptides
Polymers
Rhodamines
Polyethylene Glycols
arginyl-glycyl-aspartic acid
rhodamine B