TFAA/H3PO4 mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells

Org Biomol Chem. 2014 Aug 28;12(32):6080-4. doi: 10.1039/c4ob00686k. Epub 2014 Jul 9.

Abstract

For the first time TFAA/H3PO4 has facilitated the direct and metal-free N-acylation of carbazoles leading to a number of N-acylated derivatives. Several of these compounds were found to be promising when tested for their anti-proliferative properties against oral cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Anhydrides / chemistry*
  • Acylation
  • Carbazoles / pharmacology*
  • Carboxylic Acids / chemistry
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Fluoroacetates / chemistry*
  • HEK293 Cells
  • Humans
  • Neoplasms / pathology*
  • Phosphoric Acids / chemistry*
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / pharmacology*
  • Stereoisomerism

Substances

  • Acetic Anhydrides
  • Carbazoles
  • Carboxylic Acids
  • Fluoroacetates
  • Phosphoric Acids
  • Small Molecule Libraries
  • trifluoroacetic anhydride
  • phosphoric acid