Comparison of repaglinide and metformin versus metformin alone for type 2 diabetes: a meta-analysis of randomized controlled trials

Jinjin Yin; Houliang Deng; Shumin Qin; Waijiao Tang; Lu Zeng; Benjie Zhou

doi:10.1016/j.diabres.2014.06.009

Comparison of repaglinide and metformin versus metformin alone for type 2 diabetes: a meta-analysis of randomized controlled trials

Diabetes Res Clin Pract. 2014 Sep;105(3):e10-5. doi: 10.1016/j.diabres.2014.06.009. Epub 2014 Jun 23.

Authors

Jinjin Yin¹, Houliang Deng¹, Shumin Qin², Waijiao Tang³, Lu Zeng³, Benjie Zhou⁴

Affiliations

¹ Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, PR China; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
² Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, PR China.
³ Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
⁴ Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China. Electronic address: zhoubj163@163.com.

PMID: 25005849
DOI: 10.1016/j.diabres.2014.06.009

Abstract

We conducted a meta-analysis to compare the efficacy and safety of repaglinide plus metformin with metformin alone on type 2 diabetes. Twenty-two studies were included in this meta-analysis. Results showed combination therapy was safe and could gain better outcomes in glycemic control. Well-designed studies are required to confirm this conclusion.

Keywords: Combination therapy; Meta-analysis; Metformin; Repaglinide; Type 2 diabetes mellitus.

Publication types

Meta-Analysis
Review

MeSH terms

Carbamates / adverse effects
Carbamates / therapeutic use*
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / drug therapy*
Drug Therapy, Combination / adverse effects
Glycated Hemoglobin / analysis
Humans
Hypoglycemic Agents / adverse effects
Hypoglycemic Agents / therapeutic use*
Metformin / adverse effects
Metformin / therapeutic use*
Piperidines / adverse effects
Piperidines / therapeutic use*

Substances

Carbamates
Glycated Hemoglobin A
Hypoglycemic Agents
Piperidines
repaglinide
Metformin