Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption

Haematologica. 2014 Nov;99(11):e231-4. doi: 10.3324/haematol.2014.108365. Epub 2014 Jul 4.
No abstract available

Keywords: 17p deletion; CLL; CN-arrays; IGHV; TP53; genome complexity.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Heterogeneity*
  • Genomics
  • Humans
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / mortality*
  • Mutation*
  • Prognosis
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Tumor Suppressor Protein p53