Tissue engineering of the esophagus

Panagiotis Maghsoudlou; Simon Eaton; Paolo De Coppi

doi:10.1053/j.sempedsurg.2014.04.003

Tissue engineering of the esophagus

Semin Pediatr Surg. 2014 Jun;23(3):127-34. doi: 10.1053/j.sempedsurg.2014.04.003. Epub 2014 Apr 18.

Authors

Panagiotis Maghsoudlou¹, Simon Eaton¹, Paolo De Coppi²

Affiliations

¹ Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK.
² Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford St, London WC1N 1EH, UK. Electronic address: p.decoppi@ucl.ac.uk.

PMID: 24994526
DOI: 10.1053/j.sempedsurg.2014.04.003

Abstract

Esophageal atresia occurs in 1 out of 3000 births. Current treatments involve esophageal replacement by using more distal parts of the gastrointestinal tract, such as the stomach, jejunum, and colon. Significant complications are associated with each treatment option. Tissue engineering may provide a therapeutic alternative for esophageal replacement. This article addresses the progress in esophageal tissue engineering using acellular and cell-seeded approaches. In addition, we discuss the potential direction of future approaches by critically appraising the results in the recent literature.

Keywords: Acellular approach; Cell-seeded approach; Esophageal replacement; Tissue engineering.

Publication types

Review

MeSH terms

Acellular Dermis
Bioreactors
Esophageal Atresia / surgery*
Esophagus* / transplantation
Guided Tissue Regeneration / methods*
Humans
Tissue Engineering / methods*
Tissue Scaffolds*