Abstract
A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro α-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.
Keywords:
Clausena lansium; Rutaceae; antibacterial activity; carbazole alkaloids; α-glucosidase inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Anti-Bacterial Agents / pharmacology
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Clausena / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Glycoside Hydrolase Inhibitors / chemistry
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Glycoside Hydrolase Inhibitors / isolation & purification*
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Glycoside Hydrolase Inhibitors / pharmacology
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
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Staphylococcus aureus / drug effects*
Substances
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Alkaloids
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Anti-Bacterial Agents
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Carbazoles
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Drugs, Chinese Herbal
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Glycoside Hydrolase Inhibitors
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claulansine K