A femtogram level competitive immunoassay of mercury(II) based on surface-enhanced Raman spectroscopy

Chem Commun (Camb). 2014 Aug 21;50(65):9112-4. doi: 10.1039/c4cc03323j.

Abstract

A femtogram level and specific surface enhanced Raman spectroscopy (SERS) based competitive immunoassay was developed to detect Hg(II) in aqueous solution for the first time. This novel approach provides an alternative, ultrasensitive and specific analytical method for the detection of Hg(II).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / immunology
  • Benzoates / chemistry
  • Environmental Pollutants / analysis*
  • Environmental Pollutants / immunology
  • Gold / chemistry
  • Immobilized Proteins / chemistry
  • Immobilized Proteins / immunology
  • Immunoassay
  • Mercury / analysis*
  • Mercury / immunology
  • Metal Nanoparticles / chemistry
  • Spectrum Analysis, Raman
  • Sulfhydryl Compounds / chemistry

Substances

  • Antibodies, Monoclonal
  • Benzoates
  • Environmental Pollutants
  • Immobilized Proteins
  • Sulfhydryl Compounds
  • 4-mercaptobenzoate
  • Gold
  • Mercury