In China, hyperbaric oxygen (HBO2) has been widely applied in the treatment of ischemia/hypoxia related diseases including decompression sickness, carbon monoxide poisoning, diabetic foot ulcer and others. Wounds after skin grafts are an indication for HBO2 therapy in the Chinese Guideline for Hyperbaric Oxygen Therapy. In this study, we retrospectively reviewed the available studies on the application of HBO2 in the management of skin flaps. The mechanisms underlying the therapeutic effects of HBO2 were summarized, and therapeutic aspects in the HBO2 therapy of skin flaps in China were also described. Finally, some important issues influencing the therapeutic efficacy and further systemic reviews are proposed. Our findings may help to improve the quality of future studies in this field and to more rationally apply HBO2 therapy in patients receiving skin grafting procedures.