Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction

Jpn J Cancer Res. 1989 Feb;80(2):102-6. doi: 10.1111/j.1349-7006.1989.tb02274.x.

Abstract

By using polymerase chain reaction and differential hybridization, point mutations of N-ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N-ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Marrow / pathology
  • Bone Marrow Transplantation
  • DNA Probes
  • DNA, Neoplasm / genetics
  • Female
  • Gene Amplification
  • Genes, ras*
  • Humans
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Myelodysplastic Syndromes / genetics*

Substances

  • DNA Probes
  • DNA, Neoplasm