Functional genomics and target gene validation in experimental and human disease

Johannes H Schulte; Julika Pitsch; Albert J Becker

doi:10.1016/j.ddtec.2004.08.007

Functional genomics and target gene validation in experimental and human disease

Drug Discov Today Technol. 2004 Oct;1(2):105-11. doi: 10.1016/j.ddtec.2004.08.007.

Authors

Johannes H Schulte¹, Julika Pitsch², Albert J Becker³

Affiliations

¹ University Children's Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany.
² Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany.
³ Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany. Electronic address:albert_becker@uni-bonn.de.

PMID: 24981379
DOI: 10.1016/j.ddtec.2004.08.007

Abstract

In contrast to rare monogenic disorders related to mutations in distinct genes, frequent multifactorial diseases including complex neuronal disorders as well as neoplasms involve expression changes in a multitude of genes. The integration of data derived from human disease tissue and of animal models by data mining constitutes a recent approach to increase the pathogenetic significance of target genes. Functional validation by animal models represents a key step to develop new treatment pathways for common disorders.: