A modular electrochemical peptide-based sensor for antibody detection

Chem Commun (Camb). 2014 Aug 18;50(64):8962-5. doi: 10.1039/c4cc02858a.

Abstract

We report a modular electrochemical peptide-based sensor targeting the anti-deamidated gliadin peptide (DGP) antibody. A recognition peptide, here DGP, is grafted onto a supporting peptide bearing a redox label. The fabricated peptide-based sensor supports the detection of the target antibody (anti-DGP antibody) in the nanomolar range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / analysis*
  • Electrochemistry
  • Electrodes
  • Gliadin / chemistry
  • Gliadin / immunology*
  • Gold / chemistry
  • Methylene Blue
  • Peptide Fragments / chemistry
  • Peptide Fragments / immunology*

Substances

  • Antibodies
  • Peptide Fragments
  • Gold
  • Gliadin
  • Methylene Blue