1 Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan ; School of Medicine, China Medical University, Taichung 404, Taiwan ; Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan.
2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077.
3 Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.