A novel potentiometric sensor for determination of neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid

Biomed Res Int. 2014:2014:251653. doi: 10.1155/2014/251653. Epub 2014 May 20.

Abstract

A novel potentiometric sensor based on ionophore (Cd(NH2CH2CH2OCH2CH2OCH2CH2NH2)Ag3(CN)5) for the determination of β-N-oxalyl-L-α, β-diaminopropionic acid (ODAP) is developed. The ODAP-selective membrane sensor demonstrates high sensitivity and short response time. The detection limit of the ODAP-selective membrane sensor is about 2 × 10(-6) mol L (-1) and the response time is shorter than 6 s. The linear dynamic range of the ODAP-selective membrane sensor is between ODAP concentrations of 1.0 × 10(-2) and 1 × 10(-6) mol L (-1). The ODAP-selective membrane sensor exhibits good operational stability for at least one week in dry conditions at 4-6°C. It has a reproducible and stable response during continuous work for at least 10 h with a relative standard deviation of 0.28% (n = 18).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Diamino / analysis*
  • Calibration
  • Ionophores / chemistry
  • Limit of Detection
  • Neurotoxins / analysis*
  • Potentiometry / instrumentation
  • Potentiometry / methods*
  • Reproducibility of Results
  • Time Factors

Substances

  • Amino Acids, Diamino
  • Ionophores
  • Neurotoxins
  • oxalyldiaminopropionic acid