A new sesquiterpene lactone from the fruits of Illicium henryi

Chin J Nat Med. 2014 Jun;12(6):477-80. doi: 10.1016/S1875-5364(14)60074-1.

Abstract

Aim: To study the chemical constituents of the fruits of Illicium henryi.

Method: Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses.

Results: Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone (1), cycloparvifloralone (2), 2α-hydroxycycloparviforalone (3), henrylactone B (4), merrillianone (5), henrylactone C (6) and 7, 14-ortholactone- 3-hydroxyfloridanolide (7).

Conclusion: Compound 1 is a new sesquiterpene lactone. The tested compounds showed weak anti-HBV activities on HBV surface antigen (HBsAg) secretion and HBV e antigen (HBeAg) secretion using Hep G2.2.15 cell line.

Keywords: Anti-HBV activity; Illicium henryi; Sesquiterpene lactones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology
  • Fruit / chemistry*
  • Hep G2 Cells
  • Hepatitis B virus / drug effects
  • Humans
  • Illicium / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • 10-benzoyl-cycloparvifloralone
  • Antiviral Agents
  • Plant Extracts
  • Sesquiterpenes