Cytochalasins from cultures of endophytic fungus Phoma multirostrata EA-12

J Antibiot (Tokyo). 2015 Jan;68(1):23-6. doi: 10.1038/ja.2014.87. Epub 2014 Jun 25.

Abstract

Two new cytochalsians, multirostratin A (1) and 20-oxo-deoxaphomin (2), together with five known analogues (3-7), were obtained from the endophytic fungus Phoma multirostrata EA-12. The structures of 1 and 2 were elucidated by MS and 1D- and 2D-NMR spectroscopic data analyses, as well as by comparison of data with those of analogues reported in the literature. Compounds 1 and 2 showed moderate cytotoxicity against five tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW-480).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Ascomycota / metabolism*
  • Cell Line, Tumor
  • Cytochalasins / chemistry
  • Cytochalasins / isolation & purification
  • Cytochalasins / pharmacology*
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods
  • Neoplasms / drug therapy*
  • Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Cytochalasins