Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro

T A Baeva; S V Gein; M S Kuyukina; I B Ivshina; O A Kochina; V A Chereshnev

doi:10.1007/s10517-014-2534-9

Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro

Bull Exp Biol Med. 2014 Jun;157(2):238-42. doi: 10.1007/s10517-014-2534-9. Epub 2014 Jun 24.

Authors

T A Baeva¹, S V Gein, M S Kuyukina, I B Ivshina, O A Kochina, V A Chereshnev

Affiliation

¹ Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm', Russia.

PMID: 24958374
DOI: 10.1007/s10517-014-2534-9

Abstract

Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignificantly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Glycolipids / chemistry
Glycolipids / pharmacology*
Humans
Interleukin-8 / metabolism
Neutrophils / drug effects*
Neutrophils / metabolism*
Reactive Oxygen Species / metabolism
Rhodococcus / chemistry*
Surface-Active Agents / pharmacology*
Tumor Necrosis Factor-alpha / metabolism

Substances

Glycolipids
Interleukin-8
Reactive Oxygen Species
Surface-Active Agents
Tumor Necrosis Factor-alpha